Neonatal dosing

Specific neonatal antimicrobial dosing – Australasian Neonatal Medicines Formulary (ANMF)

Antimicrobial Link to recommended guideline/resource
Aciclovir IV ANMF – Aciclovir monograph (2021)
Amikacin IV ANMF – Amikacin monograph (2021)
Ampicillin IV ANMF – Ampicillin monograph (2021)
Amoxicillin IV ANMF – Amoxicillin monograph (2021)
Azithromycin IV ANMF – Azithromycin monograph (2022)
Benzylpenicillin IV ANMF – Benzylpenicillin monograph (2021)
Cefalexin PO ANMF – Cefalexin monograph (2020)
Cefazolin IV ANMF – Cefazolin monograph (2021)
Comment: Does not provide CNS cover – seek ID advice
Cefotaxime IV ANMF – Cefotaxime monograph (2020)
Ceftazidime IV ANMF – Ceftazidime monograph (2022)
Clindamycin IV ANMF – Clindamycin monograph (2022)
Comment: Does not provide CNS cover – seek ID advice
Flucloxacillin IV ANMF – Flucloxacillin monograph (2020)
Comment: Higher oral mg/kg doses may be required in neonates – see AMH CDC for dosing recommendations
Gentamicin IV ANMF – Gentamicin monograph (2021)
Comment: TDM required. Seek AMS/ Paediatric pharmacist advice.
Meropenem IV ANMF – Meropenem monograph (2021)
Metronidazole IV ANMF – Metronidazole monograph (2020)
Piperacillin/
Tazobactam IV
ANMF – Piperacillin/Tazobactam monograph (2020)
Comment: Does not provide CNS cover – seek ID advice
Tobramycin IV ANMF – Tobramycin monograph (2020)
Comment: TDM required. Seek AMS/ Paediatric pharmacist advice.
Trimethoprim/
sulfamethoxazole PO
ANMF – Trimethoprim/sulfamethoxazole monograph (2022)
Caution: Kernicterus risk in neonates – seek ID advice
Vancomycin IV ANMF – Vancomycin monograph (2020)
Comment: TDM required. Seek AMS/ Paediatric pharmacist advice.