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50mg tablet


Alternative to a naloxone infusion in the management of prolonged opioid toxicity in opioid naïve patients (e.g. accidental paediatric exposures).

  • ALERT – Consultation with a clinical toxicologist is recommended through a local toxicology service or Poisons Information Centre 13 11 26.


Management of opioid toxicity in opioid naïve patients

  • 50mg daily PO

Stocking recommendations

Tertiary centre Regional centre Rural centre Remote centre

30 tablets

30 tablets 0 tablets 0 tablets


Naltrexone stocking is recommended in facilities that would normally manage people who require naloxone infusions. In the uncommon scenario where patients are opioid naïve, naltrexone can be used as an alternative to a naloxone infusion.


Naltrexone should not be given to opioid-dependent patients as it will reliably cause acute opioid withdrawal.


Fact sheet developed by Queensland Poisons Information Centre, Updated: July 2020.

This fact sheet is about the use of these antidotes in Australia, and may not apply to other countries. Children’s Health Queensland Hospital and Health Service cannot be held responsible for the accuracy of information, omissions of information, or any actions that may be taken as a consequence of reading this fact sheet.