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Lipid Emulsion

Presentation

20% in 500mL

Role

  • Lipid emulsion may be considered in cases of local anaesthetic induced cardiac toxicity, in conjunction with standard resuscitative measures.
  • There is little evidence to support lipid emulsion use in the treatment of other forms of poisoning (e.g. beta-blocker, calcium channel blocker).
Lipid emulsion
  • ALERT – Consultation with a clinical toxicologist is recommended through the local toxicology service or Poisons Information Centre 13 11 26.

Dose

Give 1.5mL/kg 20% as a bolus IV over 1 minute then 0.25mL/kg/min for 30 minutes or until haemodynamic stability is restored.

Stocking recommendations

Lipid emulsion is readily available for other uses in the hospital including parenteral nutrition. Specific stocking for use as an antidote is not recommended given its limited indications for use.

Precautions

Lipid emulsion has the potential to interfere with other life-saving treatments, including clogging dialysis and ECMO circuits and interfering with subsequent laboratory assays.

Disclaimer

Fact sheet developed by Queensland Poisons Information Centre, Updated: July 2020.

This fact sheet is about the use of these antidotes in Australia, and may not apply to other countries. Children’s Health Queensland Hospital and Health Service cannot be held responsible for the accuracy of information, omissions of information, or any actions that may be taken as a consequence of reading this fact sheet.

CHQ