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Fomepizole 4-methypyrazole

Presentation

1.5g/1.5mL

Role

Management of suspected or confirmed toxic alcohol poisoning in consultation with a clinical toxicologist.

fomepizole
  • ALERT – All cases of suspected toxic alcohol poisoning should be discussed with a clinical toxicologist through local toxicology service or Poisons Information Centre 13 11 26.

Dose

  • Loading dose: 15mg/kg IV
  • Maintenance dose: 10mg/kg q12h for first 48hrs, then 15mg/kg q12h

Stocking recommendations

Tertiary centre Regional centre Rural centre Remote centre

4 vials

0 vials 0 vials 0 vials

Rationale

Given its prohibitive cost, and the easy availability of ethanol as an effective alternative antidote, fomepizole is currently only suggested for use in paediatric patients. Given all patients will require tertiary level care, stocking of fomepizole is only recommended at Queensland Children’s Hospital and Townsville Hospital.

Disclaimer

Fact sheet developed by Queensland Poisons Information Centre, Updated: July 2020.

This fact sheet is about the use of these antidotes in Australia, and may not apply to other countries. Children’s Health Queensland Hospital and Health Service cannot be held responsible for the accuracy of information, omissions of information, or any actions that may be taken as a consequence of reading this fact sheet.

CHQ