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Antivenom: Brown snake

Presentation

4.5 – 9mL vial

*KEEP REFRIGERATED*

Contains

1000 units of Brown Snake Antivenom

Role

  • Management of brown snake envenomation. Brown snake envenomation results in a venom-induced consumption coagulopathy (VICC), sudden collapse and thrombotic microangiopathy.
  • In combination with tiger snake antivenom, to treat undifferentiated snake envenomation with VICC in South East Queensland.
Antivenom: Brown Snake
  • ALERT – Consultation with a clinical toxicologist is recommended through local toxicology service or Poisons Information Centre 13 11 26

Dose

1 vial administered IV over 15 min following a 1:10 dilution with sodium chloride 0.9%. Dilution can be 1:5 in young children or patients on fluid restriction.

Stocking recommendations

Tertiary centre Regional centre Rural centre Remote centre
2 vials 1 vial 0 – 1 vial 0 vials

Rationale

In most parts of Southern Queensland one vial of brown snake AV and one vial of tiger snake AV is sufficient to cover all snakes that cause a VICC. The 2 vials of monovalent antivenom are smaller volume and less expensive than 1 vial of polyvalent antivenom.

Precautions

  • Hypersensitivity reactions may occur. Antivenom should be administered in a critical care area in anticipation of potential anaphylaxis.
  • Premedication with steroids/adrenaline is not recommended.
  • If a hypersensitivity reaction occurs, pause the infusion and treat along standard lines. Recommence the infusion once the reaction settles at a slower rate.
  • If the hypersensitivity reaction is severe, discuss the case with a clinical toxicologist.

Serum sickness may occur 4 to 14 days following the administration of antivenom. Symptoms include fever, rash, joint and muscle pain, headache, nausea and vomiting.  Patients should be informed of the symptoms and present to their local doctor should they occur.

Disclaimer

Fact sheet developed by Queensland Poisons Information Centre, Updated: July 2020.

This fact sheet is about the use of these antidotes in Australia, and may not apply to other countries. Children’s Health Queensland Hospital and Health Service cannot be held responsible for the accuracy of information, omissions of information, or any actions that may be taken as a consequence of reading this fact sheet.

CHQ